Johnny Depp 
 as Raoul Duke

Benicio del Toro 
 as Dr. Gonzo

Tobey Maguire 
 as Hitchhiker

Michael Lee Gogin 
 as Uniformed Dwarf

Larry Cedar 
 as Car Rental Agent - Los Angeles

Brian Le Baron 
 as Parking Attendant

Katherine Helmond 
 as Desk Clerk at Mint Hotel

Michael Warwick 
 as Bell Boy

Craig Bierko 
 as Lacerda

Tyde Kierney 
 as Reporter

Mark Harmon 
 as Magazine Reporter

Tim Thomerson 
 as Hoodlum

Richard Riehle 
 as Dune Buggy Driver

Ransom Gates 
 as Dune Buggy Passenger

Frank Romano 
 as Dune Buggy Passenger

Gil Boccaccio 
 as Desert Room Doorman

Gary Bruno 
 as Desert Room Doorman

Richard Portnow 
 as Wine Colored Tuxedo

Debbie Reynolds 
 as Debbie Reynolds (voice)

Steve Schirripa 
 as Goon

Verne Troyer 
 as Wee Waiter

Will Blount 
 as The Black Guy

Ben Yeagar 
 as Clown Barker

Penn Jillette 
 as Carnie Talker

Christopher Callen 
 as Bazooko Circus Waitress

Cameron Diaz 
 as Blonde TV Reporter

Benjamin A. Van Der Veen 
 as TV Crew Man

Lyle Lovett 
 as Road Person

Flea 
 as Musician

Alex Craig Mann 
 as Stockbroker

Gregory Itzin 
 as Mint Hotel Clerk

Gary Busey 
 as Highway Patrolman

Troy Evans 
 as Police Chief

Gale Baker 
 as Police Chief's Wife

Christopher Meloni 
 as Clerk at Flamingo Hotel

Christina Ricci 
 as Lucy

Chris Hendrie 
 as Executive Director

Larry Brandenburg 
 as Cop in Car

Michael Jeter 
 as Ron Bumquist

Donald Morrow 
 as Film Narrator (voice)

Harry Dean Stanton 
 as Judge

Jenette Goldstein 
 as Maid

Stephen Bridgewater 
 as Human Cannonball

Buck Holland 
 as Shopper

Mary Gillis 
 as Shopper

Jennifer Elise Cox 
 as Shopper

Robert Allen 
 as Car Rental Agent - Los Angeles

David Brisbin 
 as Man in Car

Ellen Barkin 
 as Waitress at North Star Cafe

James O'Sullivan 
 as TV Newsman

Milt Tarver 
 as TV Newsman

Kathryn Alexander 
 as Lizard Performer

Mia Babalis 
 as Lizard Performer

Kristin Draudt 
 as Lizard Performer

Kim Flowers 
 as Lizard Performer

Trudi Forristal 
 as Lizard Performer

Nan Friedman 
 as Lizard Performer

Judith Lieff 
 as Lizard Performer

Tane McClure 
 as Lizard Performer

Diana Mehoudar 
 as Lizard Performer

Geoffrey Nimmer 
 as Lizard Performer

Marlene Bologna 
 as Trapeze Artist

Chobi Gyorgy 
 as Trapeze Artist

Karen Price 
 as Trapeze Artist

Lisa Hoyle 
 as Trapeze Artist

Joseph S. Griffo 
 as Trapeze Artist

Laraine Newman 
 as Frog-Eyed Woman (uncredited)

Hunter S. Thompson 
 as Other Duke in Matrix Flashback (uncredited)