Clint Eastwood 
 as Blondie

Eli Wallach 
 as Tuco Ramirez

Lee Van Cleef 
 as Sentenza / Angel Eyes

Aldo Giuffrè 
 as Alcoholic Union Captain

Luigi Pistilli 
 as Father Pablo Ramirez

Rada Rassimov 
 as Maria

Enzo Petito 
 as Storekeeper

Claudio Scarchilli 
 as Tuco Henchman

Antonio Casale 
 as Bill Carson / Jackson

Livio Lorenzon 
 as Baker

Sandro Scarchilli 
 as Tuco Henchman

Benito Stefanelli 
 as Member of Angel Eyes' Gang

Angelo Novi 
 as Monk

Antonio Casas 
 as Stevens

Aldo Sambrell 
 as Member of Angel Eyes' Gang

Al Mulock 
 as One-Armed Bounty Hunter

Sergio Mendizábal 
 as Blonde Bounty Hunter

Antonio Molino Rojo 
 as Captain Harper

Lorenzo Robledo 
 as Clem

Mario Brega 
 as Corporal Wallace

Chelo Alonso 
 as Stevens' Wife (uncredited)

Fortunato Arena 
 as 1st Sombrero Onlooker at Tuco's 1st Hanging (uncredited)

Román Ariznavarreta 
 as Bounty Hunter (uncredited)

Silvana Bacci 
 as Mexican Woman with Blondie (uncredited)

Joseph Bradley 
 as Old Soldier (uncredited)

Frank Braña 
 as Bounty Hunter #2 (uncredited)

Amerigo Castrighella 
 as 2nd Sombrero Onlooker at Tuco's 1st Hanging (uncredited)

Saturno Cerra 
 as Bounty Hunter (uncredited)

William Conroy 
 as Confederate Soldier (uncredited)

Axel Darna 
 as Dying Confederate Soldier (uncredited)

Tony Di Mitri 
 as Deputy (uncredited)

Gianni Di Segni 
 as Deputy at 1st Hanging (uncredited)

Alberigo Donadeo 
 as Spectator Before Hanging (uncredited)

Attilio Dottesio 
 as 3rd Sombrero Onlooker at Tuco's 1st Hanging (uncredited)

Luis Fernández de Eribe 
 as Soldier Coat (uncredited)

Veriano Ginesi 
 as Bald Onlooker at Tuco's 1st Hanging (uncredited)

Jesús Guzmán 
 as Pardue the Hotel Owner (uncredited)

Víctor Israel 
 as Sergeant at Confederate Fort (uncredited)

Nazzareno Natale 
 as Mexican Bounty Hunter (uncredited)

Ricardo Palacios 
 as Barista a Socorro (uncredited)

Antonio Palombi 
 as Old Sergeant (uncredited)

Romano Puppo 
 as Member of Angel Eyes' Gang (uncredited)

Antoñito Ruiz 
 as Stevens' Youngest Son (uncredited)

Aysanoa Runachagua 
 as Pistolero Recruited by Tuco in the Cave (uncredited)

Enrique Santiago 
 as Mexican Bounty Hunter (uncredited)

José Terrón 
 as Thomas 'Shorty' Larson (uncredited)

Franco Tocci 
 as Union Soldier with Cigar (uncredited)

Antonio Montoya 
 as Mexican Bounty Hunter (uncredited)