Rainn Wilson 
 as Frank Darbo

Elliot Page 
 as Libby

Liv Tyler 
 as Sarah

Kevin Bacon 
 as Jacques

Gregg Henry 
 as Detective John Felkner

Michael Rooker 
 as Abe

Andre Royo 
 as Hamilton

Sean Gunn 
 as Toby

Stephen Blackehart 
 as Quill

Linda Cardellini 
 as Pet Store Employee

Nathan Fillion 
 as The Holy Avenger

Don Mac 
 as Mr. Range

Gerardo Davila 
 as Cop

Grant Goodman 
 as Young Frank

Paul T. Taylor 
 as Frank Sr.

Connor Day 
 as Teenage Frank

James Gunn 
 as Demonswill

Mikaela Hoover 
 as Holly

Nick Holmes 
 as Jim

Matt Moore 
 as Jesus / Guy In Line

Rob Zombie 
 as Voice Of God (voice)

Steve Agee 
 as Comic Book Store Jerk

Laurel Whitsett 
 as Librarian

James Lentzsch 
 as Passenger Teen

Nate Rubin 
 as Driving Teen

Edrick Browne 
 as Nathaniel

Danny Cosmo 
 as Purse-snatcher

Krystal Mayo 
 as Wheelchair Woman

Russell Towery 
 as Chickenhawk

Mario Jiminez Jr. 
 as Chicken

Jonathan Winkler 
 as Transvestite

Mollie Milligan 
 as Sarah's Sister

Gerry May 
 as Newscaster

Valentine Miele 
 as Line Butter

Michelle Gunn 
 as Line Butter's Girlfriend

Darcel White Moreno 
 as Waitress

Greg Ingram 
 as Long-haired Hood

Lindsey Soileau 
 as Libby's Friend

Brandon Belknap 
 as Christian

Zach Gilford 
 as Jerry

Lloyd Kaufman 
 as 911 Man

Tim J. Smith 
 as Range's Technician

Mark De Alessandro 
 as Thug Jumped On By Boltie

Cole S. McKay 
 as Thug Set On Fire

Dominick LaBanca 
 as Thug #1

John W. Lawson 
 as Thug Missing Arms

William Katt 
 as Sgt. Fitzgibbon

Christine Bently 
 as Stoner Girl