Ellen Burstyn 
 as Sara Goldfarb

Jared Leto 
 as Harry Goldfarb

Jennifer Connelly 
 as Marion Silver

Marlon Wayans 
 as Tyrone C. Love

Christopher McDonald 
 as Tappy Tibbons

Louise Lasser 
 as Ada

Marcia Jean Kurtz 
 as Rae

Janet Sarno 
 as Mrs. Pearlman

Suzanne Shepherd 
 as Mrs. Scarlini

Joanne Gordon 
 as Mrs. Ovadia

Charlotte Aronofsky 
 as Mrs. Miles

Mark Margolis 
 as Mr. Rabinowitz

Michael Kaycheck 
 as Donut Cop

Jack A. O'Connell 
 as Corn Dog Stand Boss

Chas Mastin 
 as Lyle Russel

Ajay Naidu 
 as Mailman

Sean Gullette 
 as Arnold the Shrink

Samia Shoaib 
 as Nurse Mall

Peter Maloney 
 as Dr. Pill

Abraham Abraham 
 as King Neptune

Aliya Campbell 
 as Alice

Te'ron A. O'Neal 
 as Young Tyrone

Denise Dowse 
 as Tyrone's Mother

Bryan Chattoo 
 as Brody

Eddie De Harp 
 as Brody's Henchman Victor

Scott Franklin 
 as Jailer (voice)

Peter Cheyenne 
 as Sal the Geep

Brian Costello 
 as First AD

Abraham Aronofsky 
 as Newspaper Man on Train

James Chinlund 
 as Space Oddity

Olga Merediz 
 as Malin & Block Secretary

Allison Furman 
 as Malin & Block Office Woman

Robert Dylan Cohen 
 as Paramedic Greenhill

Ben Shenkman 
 as Dr. Spencer

Keith David 
 as Big Tim

Dylan Baker 
 as Southern Doctor

Shaun O'Hagan 
 as Ward Attendant Seto

Leland Gantt 
 as Ward Attendant Penn

Bill Buell 
 as Court Doctor

Jimmie Ray Weeks 
 as Prison Guard

Gregg Bello 
 as E.R. Doctor

Henry Stram 
 as ECT Technician

Heather Litteer 
 as Big Tim Party Girl

Jenny Decker 
 as Big Tim Party Girl

Ami Goodheart 
 as Big Tim Party Girl

Nina Zavarin 
 as Big Tim Party Girl

Stanley B. Herman 
 as Uncle Hank

Scott Bader 
 as Party Animal

Jim Centofanti 
 as Party Animal

Scott Chait 
 as Party Animal

Daniel Clarin 
 as Party Animal

Ben Cohen 
 as Party Animal

Eric Cohen 
 as Party Animal

Brett Feinstein 
 as Party Animal

Ricky Fier 
 as Party Animal

John Getz 
 as Party Animal

Andrew Kessler 
 as Party Animal

Ross Lombardo 
 as Party Animal

Carter Mansbach 
 as Party Animal

Scott Miller 
 as Party Animal

Todd Miller 
 as Party Animal

Joshua Pollack 
 as Party Animal

Craig Rallo 
 as Party Animal

Geordan Reisner 
 as Party Animal

Keith Scandore 
 as Party Animal

David Seltzer 
 as Party Animal

Chris Varvaro 
 as Party Animal

Ricardo Viñas 
 as Party Animal

Chad Weiner 
 as Party Animal

Jesse Weissberger 
 as Party Animal

Greg Weissman 
 as Party Animal

Hubert Selby Jr. 
 as Laughing Guard

Lianna Pai 
 as Angelic Nurse

Darren Aronofsky 
 as Visitor (uncredited)