Billy Crudup 
 as Russell Hammond

Frances McDormand 
 as Elaine Miller

Kate Hudson 
 as Penny Lane

Jason Lee 
 as Jeff Bebe

Patrick Fugit 
 as William Miller

Zooey Deschanel 
 as Anita Miller

Michael Angarano 
 as Young William

Anna Paquin 
 as Polexia Aphrodisia

Fairuza Balk 
 as Sapphire

Noah Taylor 
 as Dick Roswell

John Fedevich 
 as Ed Vallencourt

Mark Kozelek 
 as Larry Fellows

Philip Seymour Hoffman 
 as Lester Bangs

Liz Stauber 
 as Leslie

Jimmy Fallon 
 as Dennis Hope

Olivia Rosewood 
 as Beth from Denver

Bijou Phillips 
 as Estrella Starr

Alice Marie Crowe 
 as Mrs. Deegan

J.J. Cohen 
 as Roadie Scully

Gary Kohn 
 as Roadie Gregg

Ray Porter 
 as Roadie Mick

Mark Pellington 
 as Freddy

Eion Bailey 
 as Jann Wenner

Terry Chen 
 as Ben Fong-Torres

Rainn Wilson 
 as David Felton

Erin Foley 
 as Alison the Fact Checker

Jesse Caron 
 as Darryl

Charles Walker 
 as Principal

Jay Baruchel 
 as Vic Munoz

Pauley Perrette 
 as Alice Wisdom

Peter Frampton 
 as Reg

Zack Ward 
 as The Legendary Red Dog

Mitch Hedberg 
 as Eagles Road Manager

Devin Corey 
 as The Who Road Manager

Pete Droge 
 as Hyatt Singer

Elaine Summers 
 as Hyatt Singer

Eric Stonestreet 
 as Sheldon the Desk Clerk

Marc Maron 
 as Angry Promoter

Shane Willard 
 as Ticket Scalper

Chris McElprang 
 as Aaron Amedori

John Patrick Amedori 
 as John Patrick Amedori

Kate Peckham 
 as Quiet Girl

Julia Decker 
 as Waving Girl

Brian Vaughan 
 as Real Topeka Kid

Anthony Martelli 
 as Poolside Provocateur

Zach Clairville 
 as Acid Kid

Ian Ridgeway 
 as Topeka Partier

Isaac Curtiss 
 as Topeka Partier

Chris Lennon Davis 
 as Topeka Partier

Scott N. Stevens 
 as Co-Pilot

Kevin Sussman 
 as Lenny

Reathel Bean 
 as Warwick Hotel Clerk

Tom Riis Farrell 
 as Plaza Doctor

Laura Bastianelli 
 as Nurse

Samuel Aaron Roberson 
 as High School Band

Brian Andreasen 
 as High School Band

Jared Hren 
 as High School Band

Mary Dragicevich 
 as High School Band

Aura Barr 
 as High School Band

Daniel Wilson 
 as Journalism Teacher

William Barillaro 
 as Bus Driver

Holly Maples 
 as Flight Attendant

Matt Griesser 
 as PSA Co-Pilot

Susan Yeagley 
 as Have a Nice Day Stewardess

Nicole Spector 
 as Hippie Girl at Airport

Patrick Irmen 
 as Wanna Get High Guy

Nick Swardson 
 as Insane Bowie Fan

Cindy Weber 
 as Shocked Elevator Family

Kris Weber 
 as Shocked Elevator Family

Kimberly Weber 
 as Shocked Elevator Family

Kristin Weber 
 as Shocked Elevator Family

Samer Sourakli 
 as Mustache Boy

Michelle Moretti 
 as Swingo's Desk Clerk

Ana Maria Quintana 
 as Arizona Housekeeper

Lisa Buchignani 
 as Arizona Housekeeper

Andrew Briedis 
 as Boy with Bike (uncredited)

Greg Bronson 
 as Upscale Pedestrian (uncredited)

Mark Cirillo 
 as Bowie Groupie (uncredited)

Cindy Crowe 
 as Anita - Startled Family Member (uncredited)

Wayne Doba 
 as Leonard Barr (uncredited)

Bodhi Elfman 
 as Alice's Manager (uncredited)

Elizabeth Friedman 
 as Groupie (uncredited)

Kyle Gass 
 as Quince Allen (uncredited)

Eric Rosenberg 
 as David Bowie's Manager (uncredited)

Casey Slade 
 as Hardened Roadie (uncredited)

Marc Antonio Pritchett 
 as Superfly Pimp (uncredited)

Jimmy Star 
 as Rocker (uncredited)

Christine Vienna 
 as Groupie (uncredited)

Larry Weisberg 
 as Frampton Concertgoer (uncredited)

Jann Wenner 
 as Legend in Cab (uncredited)

Patrick Williams 
 as Roadie (uncredited)

Evis Xheneti 
 as Hippie Girl (uncredited)