Morgan Freeman 
 as Somerset

Brad Pitt 
 as Mills

Gwyneth Paltrow 
 as Tracy

John Cassini 
 as Officer Davis

Peter Crombie 
 as Dr. O'Neill

Reg E. Cathey 
 as Dr. Santiago

R. Lee Ermey 
 as Police Captain

Daniel Zacapa 
 as Detective Taylor at First Murder

Andrew Kevin Walker 
 as Dead Man at 1st Crime Scene

George Christy 
 as Workman at Door of Somerset's Office

Endre Hules 
 as Cab Driver

Hawthorne James 
 as George the Night Guard at the Library

Bob Mack 
 as Gluttony Victim

William Davidson 
 as First Guard at the Library

Bob Collins 
 as Second Guard at the Library

Jimmy Dale Hartsell 
 as Library Janitor

Richard Roundtree 
 as Talbot

Charline Su 
 as TV News Reporter

Dominique Jennings 
 as TV News Reporter

Allan Kolman 
 as First Forensic Man in the Law Office

Beverly Burke 
 as TV Anchor Woman

Gene Borkan 
 as Eli Gould - Greed Victim

Julie Araskog 
 as Mrs. Gould

Mario Di Donato 
 as Fingerprint Forensic Man in Law Office

Alfonso Freeman 
 as Fingerprint Technician

John C. McGinley 
 as California

Harrison White 
 as Cop on SWAT Team

Bob Stephenson 
 as Cop on SWAT Team

Michael Reid MacKay 
 as Victor - Sloth Victim

Richard Portnow 
 as Dr. Beardsley

Tudor Sherrard 
 as Coupon Man Outside Pizza Parlor

Mark Boone Junior 
 as Greasy F.B.I. Man

Pamala Tyson 
 as Thin Vagrant by John Doe's Apartment

Lennie Loftin 
 as Policeman Who Takes Statement from Vagrant

Sarah Reinhardt 
 as Police Sketch Artist

Emily Wagner 
 as Detective Sara at John Doe's Apartment

Martin Serene 
 as Wild Bill

Michael Massee 
 as Man in Booth at Massage Parlor

David Correia 
 as First Cop at Massage Parlor

Ron Blair 
 as Second Cop at Massage Parlor

Jennifer Mueller 
 as Lust Victim

Leland Orser 
 as Crazed Man in Massage Parlor

Lexie Bigham 
 as Sweating Cop at Massage Parlor

Evan Mirand 
 as Paramedic at Massage Parlor

Paul Eckstein 
 as Paramedic at Massage Parlor

Harris Savides 
 as 911 Operator

Rachel Flanagan 
 as Additional 911 Operator

Heidi Schanz 
 as Pride Victim

Brian Evers 
 as Duty Sergeant

Shannon Wilcox 
 as Woman Cop Behind Desk

Richard Schiff 
 as Mark Swarr

James Deeth 
 as Helicopter Pilot

John Santin 
 as Helicopter Pilot

Charles A. Tamburro 
 as SWAT Helicopter Pilot

Richmond Arquette 
 as Delivery Man

Duffy Gaver 
 as Marksman in Helicopter

Kevin Spacey 
 as John Doe

Charles S. Dutton 
 as Cop (uncredited)

Arthur Max 
 as Man in Library (uncredited)